The main features of the ebola virus

The ones who answered the call Dec. This is the campus of Eternal Love Winning Africa, a nondenominational Christian mission, comprising a school, a radio station and a hospital.

The main features of the ebola virus

Signs and symptoms of Ebola [17] Onset The length of time between exposure to the virus and the development of symptoms incubation period is between 2 and 21 days, [1] [17] and usually between 4 and 10 days. As with all filovirusesebolavirus virions are filamentous particles that may appear in the shape of a shepherd's crook, of a "U" or of a "6," and they may be coiled, toroid or branched.

The most abundant protein produced is the nucleoprotein, whose concentration in the host cell determines when L switches from gene transcription to genome replication. Replication of the viral genome results in full-length, positive-strand antigenomes that are, in turn, transcribed into genome copies of negative-strand virus progeny.

Ebola virus disease - Wikipedia

Virions bud off from the cell, gaining their envelopes from the cellular membrane from which they bud. The mature progeny particles then infect other cells to repeat the cycle.

Most people spread the virus through blood, feces and vomit. In Africa, wild animals including fruit bats are hunted for food and are referred to as bushmeat. However, the high rates of death in these species resulting from EBOV infection make it unlikely that these species represent a natural reservoir for the virus.

Index cases of EVD have often been close to recently-deforested lands. This damage occurs due to the synthesis of Ebola virus glycoprotein GPwhich reduces the availability of specific integrins responsible for cell adhesion to the intercellular structure and causes liver damage, leading to improper clotting.

The main features of the ebola virus

The widespread bleeding that occurs in affected people causes swelling and shock due to loss of blood volume.

EBOV replication overwhelms protein synthesis of infected cells and the host immune defenses. The GP forms a trimeric complexwhich tethers the virus to the endothelial cells. The sGP forms a dimeric protein that interferes with the signaling of neutrophilsanother type of white blood cell.

This enables the virus to evade the immune system by inhibiting early steps of neutrophil activation. Immune system evasion Filoviral infection also interferes with proper functioning of the innate immune system.

Laboratory testing Possible non-specific laboratory indicators of EVD include a low platelet count ; an initially decreased white blood cell count followed by an increased white blood cell count ; elevated levels of the liver enzymes alanine aminotransferase ALT and aspartate aminotransferase AST ; and abnormalities in blood clotting often consistent with disseminated intravascular coagulation DIC such as a prolonged prothrombin timepartial thromboplastin timeand bleeding time.

Isolating the virus by cell culturedetecting the viral RNA by polymerase chain reaction PCR [18] and detecting proteins by enzyme-linked immunosorbent assay ELISA are methods best used in the early stages of the disease and also for detecting the virus in human remains.

Detecting antibodies against the virus is most reliable in the later stages of the disease and in those who recover.Find helpful customer reviews and review ratings for The Hot Zone: The Terrifying True Story of the Origins of the Ebola Virus at Read honest and unbiased product reviews from our users.

23 December – An experimental Ebola vaccine was highly protective against the deadly virus in a major trial, according to results published today in The Lancet.

The vaccine is the first to prevent infection from one of the most lethal known pathogens, and the findings add weight to early.

The ones who answered the call

The ongoing Ebola virus outbreak in the Democratic Republic of the Congo has similar epidemiological features to previous Ebola virus disease outbreaks. Early detection, rapid patient isolation, contact tracing, and the ongoing vaccination programme should sufficiently control the outbreak. The forecast of the number of cases does not exceed the current capacity to respond if the.

The main features of the ebola virus

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Eisenhut’s findings made it clear that Ebola patients must be separated from the rest of the hospital population and treated by staff wearing .

TIME Person of the Year Ebola Fighters