Hopefully this will clear things up. As usual, I covered a few extra items in my response pertaining to the development and perpetuation of seizures.
It could show how an infection could cause chronic fatigue syndrome, and then seemingly disappear. It focuses on the herpesviruses. Most humans carry several of these herpesviruses in latent form unless some stressor or biological event allows them to become reactivated. The glial cells perk up remarkably in the presence of viruses, releasing all manner of pro-inflammatory and neuroexcitatory compounds proinflammatory cytokines [IL-1B, IL-6, TNF-a], glutamate, prostaglandins, nitric oxide and free radicals.
All they need to do is tweak the vagus nerve and let it and the brain the do the rest. The Key Component — Glial Cells The glial cells that surround and protect the vagus nerve are the key.
At its most extreme allodyniathe nervous system can interpret even the slightest touch as eliciting pain.
That model of pain production has been solidly documented. Herpesvirus infections of the trigeminal nerve cause shingles. Do herpesvirus infections of the vagus nerve cause chronic fatigue syndrome?
What if the vagus nerve receptors were…ceaselessly bombarded with these cytokines? The symptoms of sickness behavior would be severe and intractable. Magnetic resonance imaging MRI may be able to detect viral lesions in central nervous system tissues. The severely ill should be given a prominent place in future studies.
Glial cell inhibitors have a good safety profile, have been helpful at curbing neuropathic pain and are not used much in chronic fatigue syndrome or fibromyalgia.
If VanElzakker is right then Ibudilast, a drug in clinical trials now for another disorder, is a possibility. Ibudilast can also prevent viral activation of the microglia.
Other general microglial inhibitors exist minocyline, pentoxyfilline, propentfylline but have undesirable side effects. Antivirals Stopping glial cell activation may be easier than getting at the viruses themselves.
Herpesviruses living in the sensory ganglia may be protected from antiviral drugs and antibodies. One new herpesvirus drug may be coming on the market soon, however. Alternately, viruses other than the herpesviruses could be infecting the vagus nerve.Recent Independent Aspartame Research Results & News ( - ) The results of recent independent research continue the trend of research not funded by the manufacturer finding serious problems with aspartame ingestion.
Details about other independent research demonstrating the hazards of aspartame ingestion can be found in the Aspartame FAQs and Aspartame Scientific Abuse web . Explore the latest articles, projects, and questions and answers in Monosodium Glutamate, and find Monosodium Glutamate experts.
Research Article Monosodium Glutamate Toxic Effects and Their Implications for Human Intake: A Review Veronika Husarova and Daniela Ostatnikova Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia In this paper we review animal and human studies in which MSG effects on central nervous system, adipose.
Deciding what foods to buy was simpler when most food came from farms. Now, factory-made foods have made chemical additives a significant part of our diet. [Download] UPSC IAS/IPS CSAT Prelim General Studies Question Paper in eye Candy Fonts (Answerkey & Analysis Later) Subscribe Question-Papers Comments 1 .
Monosodium glutamate has gotten a bad rap for causing allergies, but is it justified?